Alginic acid interaction

Alginic acid/divalent cation Ionic interaction pH [27]... 

Alginic Acid + Aluminum Hydroxide Magnesium Tnsilicate (Gaviscon) [Antacid] [OTC] Uses Heartburn hiatal hernia pain Action Protective layer blocks gastric acid Dose 2—4- tabs or 15-30 mL PO qid followed by H2O Caution [B, -] Avoid in renal impair or Na -restricted diet Disp Tabs, susp SE D, constipation Interactions T Absorption OF tetracyclines EMS None OD May cause constipation, loss of appetite, muscle weakness, and peripheral edema symptomatic and supportive... 

Through our studies of alkaline earth, lanthanide, and yttrium ions, and their interaction with the polyuronide al c acid, we would like to predict the environmental behavior of the actinides. We chose to begin our study by investigating the interaction of soil constituents with the divalent alkaline earth metal ions and the trivalent lanthanides, which serve as convenient trivalent actinide analogs. Soil is primarily composed of polyelectrolytes. By choosing a simple polyelectrolyte such as the polyuronide alginic acid, we can begin to establish possible pathways of metal ion transport. 

Simpson, N. E., Stabler, C. L., Simpson, C. P., Sambanis, A., Constantinidis, I. The role of the CaClj-guluronic acid interaction on alginate encapsulated betaTC3 cells. Biomaterials. 2004, 25, 2603—2610. 

Fig. 2 Supramolecular natural polymeric hydrogels discussed in this chapter, (a) Chemical structure of the most-repeated sequence in collagen, forming the a-chain that folds in a three-stranded superhelix [135]. These superhelices bundle to fram the collagen fiber, (b) Representative chemical structure of fibroin and the antiparallel p-sheet formation connected by hydrophilic linkers, (c) Chemical structure of alginic acid, cross-linked by calcium ions (highlighted), (d) Left Top view of two a-helixes of keratin forming a coiled coll by hydrophobic interactions. Right Overview of subsequent formation of the fibril. The left part is adapted from [57] with permission of The Royal Society of Chemistry...

The addition of cationic surfactant to an anionic polysaccharide solution shows its greatest effect near the surfactant cmc. As the surfactant concentration increases beyond the cmc, the polysaccharide may go back into solution or it may form an insoluble complex, flocculate, and settle out of solution. In general, as the polysaccharide s anionic charge increases, so does its interaction with cationic surfactants. As an example, alginic acid binds more strongly to cationic surfactants than carboxymethylcellulose. 

Table 2. Interaction sites, binding energy, hydrogen bond sites, and bond distance, calculated based on the bioinformatics tool for the cross-linking between collagen (Type I) and alginic acid.

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