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Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs

A particular field of interest for the application of aldolases is in multistep and cascade reactions for the preparation of carbohydrate-hke compounds and analogs [Pg.339]

Cascade Biocatalysis Integrating Stereoselective and Environmentally Friendly Reactions, First Edition. [Pg.339]

Edited by Sergio Riva and Wolf-Dieter Fessner. [Pg.339]

Here we recount the latest research on chemoenzymatic multistep and cascade strategies for the synthesis of iminocyclitols, carbohydrates, and deoxysugars from N-protected ami noaldehydes, hydroxyaldehydes, and simple alkylaldehydes, respectively. The key step in all of them is the stereoselective aldol addition reaction of dihydroxyacetone phosphate (DHAP) and its unphosphorylated analogs to the acceptor aldehydes using DH AP-dependent and dihydroxyacetone- (DH A)-utilizing aldolases, respectively, as biocatalysts. [Pg.340]

In these reactions, RhuA was the most versatile aldolase, accepting both linear and branched C-a-substituted N-Cbz-aminoaldehydes, while FucA tolerated only C-a hnear alkane substitutions. Aware of the importance of the reaction medium, the reactions were assayed in both highly concentrated gel emulsions [17] and 1 4 N,N -dimethylformamide (DMF)/water mixtures. In this case, the 1 4 DMF/water mixtures was the reaction medium of choice providing the best conversions especially for stericaUy more demanding branched alkyl substituents [16]. [Pg.342]


I )6 Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs Table 16.1 [Continued]... [Pg.354]


See other pages where Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs is mentioned: [Pg.339]    [Pg.340]    [Pg.342]    [Pg.344]    [Pg.346]    [Pg.348]    [Pg.350]    [Pg.352]    [Pg.356]    [Pg.358]    [Pg.339]    [Pg.340]    [Pg.342]    [Pg.344]    [Pg.346]    [Pg.348]    [Pg.350]    [Pg.352]    [Pg.356]    [Pg.358]    [Pg.937]   


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Aldolase and

Analogs synthesis

Carbohydrate synthesis

Catalyst synthesis and

Synthesis of carbohydrates

Synthesis of the Catalysts

The Analogy

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