Aldehydes epichlorohydrin

Hydroxymethylation (formaldehyde) of nitro-imidazole 76 affords 77, which is oxidized to aldehyde 78. To prepare the other fragment for this convergent synthesis, reaction of epichlorohydrin with morpholine leads to the aminoepoxide 79, which is reacted with hydrazine to afford 80. Reaction of this substituted hydrazine with dimethyl carbonate affords oxazolinone 81 by sequential ester interchange reactions. Condensation of 81 with aldehyde 78 affords the antitricho-... 

Anion-exchange resins prepared from polyalkylenimine, epichlorohydrin, and third components capable of producing crosslinking have larger life times than is possible with polyalkylenimine and epichlorohydrin alone . Such useful third components include phenol, resorcinol, and aldehydes. 

Blumer described a composition which could be used in the manufacture of coatings, based on phenol aldehyde compounds reacted with epichlorohydrin. 

Alkylation of metallated a-(dialkylamino)nitriles with alkyl halides, epichlorohydrin, allyl halides or ethyl bromoacetate followed by hydrolysis furnishes an array of ketones in good yield. - For example, reaction of (42) with benzyl chloride leads to the formation of deoxybenzoins. Alkylation of a-(dialkyl-amino)nitriles is also possible if the latter are derived from aliphatic aldehydes. - ... 

One of the first papers was published by Corey on the use of bis(methylthio)allyllithium (1 Scheme 14) for the synthesis of a,p-unsaturated aldehydes from alkyl halides. The generation of the carbanion as the lithio derivative was readily accomplished by a simple three-step sequence from epichlorohydrin. 

The simplest class of hydantoin epoxy resins are the 1,3-diglycidylhydantoins of Formula II. They were readily prepared from the 5,5-dialkyl or 5-monoalkylhydantoins and epichlorohydrin. The hydantoins (Formula l) were prepared from ketones or aldehydes via the Bucherer reaction. 

Zhu and coworkers have reported the synthesis of functionalized poly(vinyl alcohol) resins for use as scavengers [13]. This was achieved via inverse suspension polymerization along side epichlorohydrin as a cross-linker. These resins were found to have excellent swelling characteristics in DMF, CH3OH, dioxane, THF, CH2C12 and H20. These were then functionalized with glutaric aldehyde to provide a polymer-supported aldehyde (Scheme 8.8). 

A10j Na Aqueous solution is a strong base. Incompatible with organic anhydrides, acrylates, alcohols, aldehydes, alkylene oxides, substituted allyls, cellulose nitrate, cresols, caprolactam solution, chlorocarbons, epichlorohydrin, ethylene dichloride, isocyanates, ketones, glycols, nitrates, phenols, vinyl acetate. Exothermic deconqjosition with maleic anhydride. May increase the explosive sensitivity of nitromethane. Attacks aluminum, copper, tin, and zinc. 

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