Alcoholism nervous system consequences

As we will see in part V, the Recreational Drugstore, many of the abused stimulant drugs that cause seizures during acute use are highly sleep suppressant through their direct action on neuromodulatory systems. Alcohol, by contrast, is a general central nervous system suppressant. As such, and in contrast to the stimulants, alcohol causes euphoria only as a relatively brief consequence of its essentially anesthetic action on the brain. By numbing the brain it induces relaxation, lifts cortical inhibition, and produces a temporary sense of comfort with the self and with society. 

The parent compound of the secoiridoids is secologa-nin (see secoiridoids), the most important intermediate in the biogenesis of alkaloids that are not derived from an amino acid. This includes most indole alkaloids, the ipecac, the Cinchona, and the pyrroloquinoline alkaloids as well as simple monoterpene alkaloids The best known biological property of the I. is their bitter taste. However, bitter principles are mostly not used as pure substances, instead alcoholic extracts are preferred to stimulate appetite (increased secretion of gastric juice). Furthermore, bitter substances are used to modify the taste of pharmaceutical products. Some I. exert various effects on the central nervous system as a consequence of their volatility and lipophilicity, e.g., nepetalactone, iridodial, teucrium lactones, and valepotriates. 

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