Alcohol, pills preparation

The first procedure was developed for the determination of several sulfonamides (sodium sulfacetamide, sulfadiazine, sulfaguanidine, sulfa-methizole, sulfamethoxazole, and sulfanilamide), in different pharmaceutical preparations (tablets, pills, capsules, drops, and suspensions), after azo dye formation. The retention of the azo dyes was excessive (analysis times longer than 40 min) wifti pure micellar SDS mobile phases. The retention times were still high (> 25 min) after addition of 1-propanol as modifier. Therefore, an alcohol giving a higher elution strength, such as 1-pentanol, was preferred. 

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