Alcaligenes faecalis var. myxogene

The inhibitory effects of berbamine and ISO natural products on the cytotoxic activity of polymorphonuclear leukocytes (PMN) was investigated. The research employed the effects of natural products on the PMN activation by the antitumor immunomodulator TAK (a linear P-1,3-D-glucan from Alcaligenes faecalis var. myxogenes) using a PMN cytotoxicity assay system. Berbamine was found to inhibit the activation of PMN activation by TAK, showing an IDJ0 33 pg/ml. From this, and related studies, it was postulated that berbamine may impair the NADPH oxidase system in the plasma membrane of PMN [199]. 

Curdlan is the extracellular polysaccharide produced by Alcaligenes faecalis var, myxogenes [10C3 (mutant K)1. Structurally, curdlan is a linear polysaccharide composed entirely of 3-1,3-glucose units. 

Curdlan Alcaligenes faecalis var. myxogenes Rhizobium Cellulomonas flavigena Pharmaceutical industries, food industries, construction fields, drug delivery and so on... 

Extracellular polysaccharide prod, by Alcaligenes faecalis var. myxogenes, structural or reserve polysaccharide of yeasts, fungi and higher plants. Gelling agent for foods. Claimed to show anti-HIV activity by inhibiting attachment of the virus to T-cells. Insol. H2O but absorbs H2O. Suspensions heated >54° form a firm gel. Phase 1 clinical trials (1995)... 

Harada T, Masada M, Fujimori K, Maeda I. Production of firm, resihent gel- forming polysaccharide by a mutant of Alcaligenes faecalis var. myxogenes 10C3. Agric Biol Chem 1966 30 196-8. 

Saito H., Ohki X, and Sasaki X. 1977. A C nuclear magnetic resonance study of gel forming (1 3)-P-D-glucans. Evidence of the presence of single-helical conformation in a resilient gel of a curdlan-type polysaccharide 13140 from Alcaligenes faecalis var. myxogenes IFD 13140. Biochemistry 16 908-914. 

Sasaki T, Abiko N, Sugino Y, Nitta K (1978) Dependence on chain length of antitumor activity of (l->3)-P-D-glucan from Alcaligenes faecalis var. myxogenes, IFO 13140, and its acid-degraded products. Cancer Res 38 379-383... 

Curdlan is an extracellular polysaccharide produced by the bacterium Alcaligenes faecalis var. myxogenes. It is also found in many yeasts and fungi as a component of cell walls or as a storage polysaccharide. 

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