Albumin organic anions binding

There have been several studies that underscore the importance of unbound concentration in cell-based studies of receptor function. In a model study of the effect of plasma protein binding on the renal transport of organic anions using the expression of various organic anion transporters (OATPs) in Xenopus oocytes, the transport of ochratoxin A, methotrexate, and estrone sulfate was found to be strongly inhibited by the addition of human serum albumin to the culture medium [16]. Similarly, the addition of oq-acid glycoprotein was found to reverse the blockade of sodium-ion current by cocaine in a preparation of cardiac myocytes [17]. 

Human plasma contains more than 60 proteins. There are three main proteins associated with the binding of drugs albumin, AAG, and lipoproteins. This article does will not review drug transport proteins of recent interest such as p-glycoproteins, organic anion transporters, and dipeptide transporters, which have been reviewed recently. 

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