Ischemia modified albumin

CLINICAL AND ANALYTICAL REVIEW OF ISCHEMIA-MODIFIED ALBUMIN MEASURED BY THE ALBUMIN COBALT BINDING TEST... [Pg.1]

Given the understanding that release of cardiac troponin into the circulation reflects myocardial cell death, it is understandable why, clinically, therapies are oriented toward inhibiting the pathophysiologic processes of thrombosis, fibrinolysis, platelet aggregation, and inflammation leading to ischemia and, ultimately, myocardial cell death. Several markers of ischemia have been proposed [2], and research and development studies are underway to adequately validate their clinical usefulness or lack of evidence. These include the topic of this chapter (ischemia-modified albumin [IMA]), as well as choline, unbound free fatty acids, and nourin. [Pg.2]

Summary of Clinical Studies Measuring Ischemia-Modified Albumin by the Albumin-Cobalt Binding Test... [Pg.4]

Quiles, 2003 [12] PCI 34 NA NA Ischemia-modified albumin changes related to number and duration of inflation during PCI Prospective enrollment... [Pg.4]

Garrido, 2004 [13] PCI 90 NA NA Ischemia-modified albumin increases related to PCI and collaterals present Prospective enrollment... [Pg.4]

Roy, 2004 [15] DCCV 24 NA NA DCCV for A fib caused increases in ischemia-modified albumin Prospective enrollment... [Pg.4]

Sinha, 2004 [16] ACS 245 72% 59% Compare PPV and NPV of ischemia-modified albumin vs. other biomarkers and electrocardiogram Prospective enrollment... [Pg.4]

Sinha MK, Gaze DC, Tippins JR, Collinson PO, Kaski JC. Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention. Circulation 2003 107 2403-2405. [Pg.10]

Quiles J, Roy D, Gaze D, et al. Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia. Am J Cardiol 2003 92 322-324. [Pg.10]

Garrido IP, Roy D, Calvino R, et al. Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals. Am J Cardiol 2004 93 88-90. [Pg.10]

Pollack CV, Peacock WF, Summers RW, et al. Ischemia-modified albumin (IMA) is useful in risk stratification of emergency department chest pain patients. Acad Emerg Med 2003 10 555-556. [Pg.10]

Sinha MK, Roy D, Gaze D, Collinson PO, Kaski JC. Role of ischemia modified albumin, a new biochemical marker of myocardial ischemia, in the early diagnosis of acute coronary syndromes. Emerg Med J 2004 21 29-34. [Pg.10]

Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobaltbinding test after a marathon race. Clin Chem 2002 48 1097-1100. [Pg.10]

Wu AHB. The ischemia-modified albumin biomarker for myocardial ischemia. Medical Laborator Observer June, 2003 36-40. [Pg.10]

Although troponin elevation suggests necrosis, biomarkers of myocardial ischemia are equally important. Ischemia-modified albumin was reported to be highly sensitive for a diagnosis of ischemia in patients with chest pain presenting to the emergency room (12). Further study needs to be done on this sensitive biomarker for myocardial ischemia. [Pg.466]

Figure 5-3. Complete spectrum of acute coronary pathophysiological process from initiation of atherosclerosis to cell death. Biomarkers released at different stages include interleukin 6 (IL-6), myeloperoxidase (MPO), soluble CD40 ligand (sCD40L), high-sensitivity C-reactive protein (Hs-CRP), ischemia-modified albumin (IMA), cardiac troponins I and T (cTnT and cTnl, respectively), B-type natriuretic peptide (BNP), and N-terminal proBNP (NT-proBNP). Of these, only the troponins and BMPs are myocardial specific.

Ischemia modified albumin (IMA), measured by the albumin cobalt binding test, has been approved by the FDA for its negative predictive value in concert with a normal EGG and a normal cardiac troponin. This test relies on changes in the binding of cobalt to the albumin molecule when ischemia is present. It requires additional vafidation of the meaning of a positive test before clinical use for ruUng in ischemia. [Pg.1635]

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