Albino phenotype

Furthermore, a melanocyte line that has reverted in culture from albino to wild type has restored the cysteine codon at position 85 (Jackson and Bennett, 1990). In vivo studies (see below) proved that the c-locus encodes tyrosinase and showed that expression of a tyrosinase minigene rescues the albino phenotype (Yokoyama et al., 1990 Tanaka et al., 1990 Beermann et al., 1990). 

Figure 4. Rescue of the albino phenotype in transgenic mice. The photograph shows a nontransgenic albino mouse, two transgenic pigmented mice (ptrTyr4 agouti coat color), and a nontransgenic C57BL/6J mouse (nonagouti black).

Beermann, F., Ruppert, S., Hummler, E., Bosch, F. X., Muller, G., Riither, U., and Schiitz, G. (1990). Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J. 9 2819-2826. 

Bredt BM, Higuera-Albino D, Shade SB, et al (2002) Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients. J Clin Pharmacol 42 82S-89S... 

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