Levamisole Albendazole

Nematodes Ascaris lumbricoides (roundworm) Pyrantel pamoate, mebendazole Albendazole, levamisole, piperazine... 

Ascnn.isis Astons JiimhrtcorfJes levamisole, rnebendazoic. pyrantel, piperazine or albendazole ... 

Thiabendazole, cambendazole, par-bendazole, mebendazole, flubenda-zole, flubendazole, fenbendazole, oxfendazole, albendazole, febantel, thiophanate, tetramisole, levamisole, piperazine, pyrantel, morantel, di-chlorovos, metrifonate, haloxon, cou-maphos, crufomate, closantel, disophenol, ivermectin... 

Mebendazole, thiabendazole, fenbendazole, albendazole, febantel, levamisole, ivermectin. 

Levamisole may markedly decrease the bioavailability of albendazole sulfoxide, but albendazole has no clinically significant effects on levamisole pharmacokinetics. 

A study in 28 healthy subjects given levamisole 2.5 mg/kg alone or with albendazole 400 mg found that albendazole produced a modest reduction in the AUC of levamisole but no other pharmacokinetic parameters were affected. However, the AUC of albendazole sulfoxide (the active metabolite) was 75% lower when given with levamisole than historical values in subjects who had received levamisole alone. An associated study in 44 patients found that levamisole with or without albendazole was not effective against Onchocerca volvulus infections. Both treatments caused a similar number of adverse effects. The clinical relevance of these findings is unclear, but they suggest that caution is needed if both drugs are to be given for systemic worm infections. 

Awadzi K, Edwards G, Opoku NO, Ardrey AE, Favager S, Ad[Pg.231]

Some antiparasitic drugs, notably the macrocyclic lactones, have already been addressed in Chapter 6. This chapter will examine the toxic effects of other compounds that are widely used, or have been used, as antiparasitic drugs in animals. In Europe and elsewhere, the main anthelmintic drugs are the benzimidazoles and levamisole. The major benzimidazole drugs are thiabendazole, albendazole, fenbendazole, flubendazole, mebendazole, oxfendazole, oxiben-dazole, triclabendazole and albendazole sulphoxide (ricobendazole, albendazole oxide). Febantel and netobimin are two prodrugs that in vivo are converted to fenbendazole and albendazole, respectively. Levamisole is the levo ( ) isomer of (dextro isomers. Tetramisole has been superseded by levamisole. These and some other antiparasitic drugs are discussed in this chapter. 

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