Agranulocytosis indometacin

ANTIPSYCHOTICS NS AIDS 1. Reports of T sedation when indometacin is added to haloperi-dol 2. Risk of agranulocytosis when azaproprazone given with clozapine 1. Unknown 2. Unknown 1. Avoid co-administration 2. Avoid co-administration... 

Blood dyscrasias, sometimes fatal aplastic anemia (21), isolated granulocytopenia, and agranulocytosis have been reported (22). The International Agranulocjdosis and Aplastic Anemia study showed that indometacin was significantly associated with agranulocjdosis and aplastic anemia (23). 

An analysis of all reports of blood disorders attributed to NSAIDs that were submitted to the Finnish National Board of Health during 1973-85 showed that metamizole was suspected of causing 14 cases of agranulocytosis (three fatal), other pyrazolones four cases, indometacin two cases, and ibuprofen one case (7). 

NSAIDs have been reported to cause potentially severe hematological disorders thrombocjdopenia, agranulocytosis, aplastic anemia, and hemolytic anemia (50). Thrombocytopenia is generally mild and reversible and has a low case-fatahty rate, but deaths from bleeding have been reported, particularly with indometacin, oxjrphen-butazone, and phenylbutazone (50). 

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