Aggregate suitability evaluation

Aggregate Suitability Evaluation. As indicated earlier, most of the mixes studied were made with medium-coarse sand. However, a number of mixes were prepared to explore the range of aggregate gradations which may benefit from sulfur addition to asphalt compositions. The gradations in Table I cover materials from fine blow sands to coarse pit... 

The compounds potently inhibit factor Xa in vitro with reversible binding kinetics and are able to inhibit not only free but also prothrombinase-bound factor Xa (Ki 41 nM, 0.1 I nM, and 0,5 nM, respectively) (58-60), In contrast, no direct effect on platelet aggregation has been described (60-62), Antithrombotic activity in arterial and venous thrombosis models has been demonstrated and it has a reduced effect on hemorrhage in comparison to standard therapy (58,60,63). Factor Xa inhibitors are able to reduce the endogenous thrombin potential in platelet-poor as well as in platelet-rich plasma (64,65). Thus, thrombin generation seems to be a suitable biomarker for clinical evaluation and has been evaluated in phase I studies (66,67). 

The effect of NAMPT inhibitors on platelets isolated from healthy human donors was also investigated. None of the three structurally distinct NAMPT inhibitors had an effect on platelet bioenergetics, aggregation, or activation up to a concentration of 50 pM, suggesting that the clinical thrombocytopenia was mainly due to effects on platelet production by megakaryocytes rather than effects on platelets (Tarrant et al., 2015). This approach illustrates the successful use of in vitro systems of primary human cells to recapitulate human toxicities when animals are not suitable models in order to evaluate MOT and also toxicity mitigation strategies. 

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