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Agenerase - Amprenavir

In July 1995, Vertex (Cambridge/MA, USA) presented encouraging preclinical and phase I results for Agenerase (amprenavir,VX-478) the compound demonstrated no toxicity for single doses up to 1200 mg but 70-78% bioavailability in tablet form and a half-life of 8 h in blood plasma, in combination with a 25-fold decrease of viral count in comparison with the base case. Even versus the most resistant HIV strain, VX-478 is only 15-fold less sensitive than against an unmutated virus. [Pg.392]

Agenerase (Amprenavir). GlaxoSmithKline UK. UK Summary of product characteristics, February 2007. [Pg.805]

Amprenavir (APV, Agenerase) is the most recently approved HIV protease inhibitor. It is smaller and stereochemically less complex than the other drugs in this class. Adsorption of this compound was found to be impaired by high fat meals. Common side effects of Amprenavir are nausea, vomiting, diarrhea, rash and a tingling sensation around the mouth. [Pg.1287]

Amprenavir, Agenerase, VX278 Glaxo-Wellcome HIV protease Transition state analog... [Pg.358]

Abacavir (Ziagen) Amprenavir (Agenerase) Delavirdine (Rescriptor) Didanosine [ddl] (Videx) Efavirenz (Sustiva) Efavirenz/Emtricitabine/ Tenofovir (Atripla) Fosamprenavir (Lexiva)... [Pg.37]

Amprenavir (Agenerase) is administered twice daily, providing the patient with an advantage over other protease inhibitors that must be taken more frequently (e.g., indinavir, saquinavir). Common side effects of am-... [Pg.592]

Oral 100 mg capsules, tablets 50 mg/5 ml syrup Amprenavir (Agenerase)... [Pg.1088]

Solutions of sodium hydroxide and/or diluted hydrochloric acid may have been added to adjust pH. Each milliliter of AGENERASE oral solution contains 46 U vitamin E in the form of TPGS. Propylene glycol is in the formulation to achieve adequate solubility of amprenavir. The recommended daily dose of AGENERASE oral solution of 22.5 mg/kg twice daily corresponds to a propylene glycol intake of 1650 mg/kg per day. [Pg.83]

Figure 13.1 Structure of VX-478 (Amprenavir, Agenerase , Vertex/Kissei/GlaxoSmithKIine). Figure 13.1 Structure of VX-478 (Amprenavir, Agenerase , Vertex/Kissei/GlaxoSmithKIine).
USAN Amprenavir Trade name Agenerase GlaxoSmithKline Launched 1999... [Pg.31]

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Agenerase

Amprenavir

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