Agelas conifera

Assmann M, Kock M (2002) Bromosceptrin, an Alkaloid from the Marine Sponge Agelas conifera. Z Naturforsch 57c 157... 

Assmann M, Lichte E, Pawlik JR, Kock M (2000) Chemical Defenses of the Caribbean Sponges Agelas wiedenmayeri and Agelas conifera. Mar Ecol Prog Ser 207 255... 

Sceptrin has also been found in several different sponges, co-occurring vith related compounds. Oxysceptrin (67), previously found by Rinehart et al. in a sample of Agelas conifera [109], vas re-isolated by Kobayashi et al. together vith sceptrin from the Okinawan sponge Agelas cf nemoechinata [110]. Its activity as an actimyosin-ATPase activator has been reported [110]. 

Numerous antiviral and antibacterial sceptrin/oxysceptrin derivatives (68-72), along with the diacetate salts of sceptrin and oxysceptrin, were isolated from Agelas conifera [104,111,112]. 

EC50 0.1-0.5mg/L dibromosceptrin from Agelas conifera (C22H22Br4N o02, Mr 778.10), actomyosin ATPase activator. 

Assmaim, M., Licthe, E., Pawlik, J. R, Kock, M., (2000). Chemical defenses of the Caribbean sponges Agelas wiedenmayeri and Agelas conifera. Mar. Ecol Prog. Ser. 207,255-262. 

Assmann, M., Kock, M., (2002). Bromosceptrin, an alkaloid from the marine sponge Agelas conifera. Z. Naturforsch. C J. Biosci. 57, 157-160. 

Keifer PA, Schwartz RE, Koker MES, Hughes RG Jr, Rittschof D, Rinehart KL (1991) Bioactive bromopyrrole metabolites from the Caribbean sponge Agelas conifera. J Org Chem 56 2965-2975... 

Duque, C., Cepeda, N., and Martinez, A. (1993) The steryl ester and phospholipid fatty adds of the sponge Agelas conifera from the Colombian Caribbean. Lipids, 28, 767-769. 

Shen, X., Perry, T.L., Dunbar, C.D., Kelly-Borges, M., and Hamann, M. T. (1998) Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera. J. Nat. Prod., 61, 1302-1303. 

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