Age-Related Changes in Renal Clearance

FIGURE 24.3 Observed drug responses in elderly patients represent the combined effects of drug input and age-related pharmacokinetic and pharmacodynamic changes. 

TABLE 24.3 Some Drugs with Decreased Clearance in the Elderly 

Renal All aminoglycosides, vancomycinm, digoxin, procainamide, lithium, sotalof atenolof dofetilide, cimetidine 

Single Phase I metabolic pathway CYP3A Alprazolam, midazolam, triazolam, verapamil, diltiazem, dihydro pyridine calcium channel blockers, lidocaine 

CYP1A2 Multiple Phase I metabolic pathways Theophylline Imipramine, desipramine, trazodone, hexobarbital, flurazepam 

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