Aerobic Carbon Monoxide Dehydrogenase

The aerobic family of CODHs are derived from aerobic bacteria. In toto, CODHs are estimated to process 10 kg y of CO. The electrons from CO oxidation are transferred through an electron transport chain that ultimately oxidizes O2. In vitro the CODH also displays some H2 oxidation catalysis. 

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The carbon monoxide dehydrogenase of the aerobe Oligotropha carboxidovorans contains both Cu and Mo in the form of a cluster in which the Mo is bound to the thiol groups of molybdopterin cytosine nucleotide, and the Cu to cysteine residue in the form of a Cu-S-Mo(=0)OFl cluster (Dobbek et al. 2002). 

XAS has also contributed substantially to our understanding of other members of this family, and in particular the novel carbon monoxide dehydrogenases. The first of these to be characterized was from the aerobic bacterium Oligotropha carboxidovorans. The enzyme catalyzes the reaction ... 

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