Adverse reactions/drug interactions

Adverse drug reactions and drug interactions W McCaughey Introduction Definitions Adverse reactions Drug interactions Pharmacokinetic Pharmacodynamic Clinically important interactions INTRODUCTION... 

Even if the herbal extract is effective, significant problems exist with its use. The content of herbal products is poorly standardized, and significant variation in supposed active ingredient content for some herbals exists from lot to lot and between manufacturers. Until these products are better standardized and their manufacturing and stability better assured, it is recommended that they be used with caution. Eurthermore, little is known abont potential adverse reactions, drug interactions, or long-term toxicity with their use. 

Evaluate the patient for the presence of adverse drug reactions, drug interactions, and allergies. 

D Arcy PF. Adverse reactions and interactions with herbal medicines. Part 2. Drug interactions. Adverse Drug React Toxicol Rev 1993 12 147-162. 

Ellinwood, E., Tong, H. (1996). Central nervous system stimulants and anorectic agents. In M. N. G. Dukes (Ed.), Meyler s side effects of drugs An encyclopedia of adverse reactions and interactions (13th ed., pp. 1-30). New York Elsevier. 

Pharmacology studies related to the therapeutic indication should be presented first, followed by those related to possible adverse reactions and interactions with other drugs. Within the three categories listed above, the data should be grouped in the following order ... 

CHAPTER 13 Antiallergy Drugs and Decongestants Table 13-4 Adverse Reactions and Interactions of Second-Generation Antihistamines ... 

Guarino, R.A. Adverse reactions and interactions of drugs. In New Drug Approval Process, 3rd Ed. Marcel Dekker, Inc. New York, 2000 100, 247. 

Several reviews of the clinical pharmacology, actions, therapeutic uses, and adverse reactions and interactions of adenosine and ATP have appeared (1-4). After intravenous administration adenosine enters cells, disappearing from the blood with a half-life of less than 10 seconds intracellularly it is phosphorylated to cyclic AMP. Its mechanism of action as an antidysrhythmic drug is not known, but it may act by an effect at adenosine receptors on the cell membrane. Its electrophysiological effects are to prolong AV nodal conduction time by prolonging the AH interval, without an effect on the HV interval. The pharmacological and adverse effects of adenosine triphosphate are similar to those of adenosine. 

Lewis RV, McDevitt DG. Adverse reactions and interactions with beta-adrenoceptor blocking drugs. Med Toxicol 1986 1(5) 343-61. 

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