Adverse drug reactions, pharmacogenetics

Hung SI, Cheeng WH, Jee SH et al (2006) Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics 16 297-306... 

Meyer, U. A. (2000). Pharmacogenetics and adverse drug reactions. Lancet, 356, 1667-71. 

Meyer, U.A., "Pharmacogenetics and Adverse Drug Reactions," Lancet, 356, 1667-1671 (2000). 

Marinaki, A. M., Ansari, A., Duley, J. A., et al. (2004) Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics. 14,181-187. 

Schwab, M Schaffeler, E Marx, C Fischer, C., Lang, T., Behrens, C., Gregor, M., Eichelbaum, M., Zanger, U.U. and Kaskas, B.A. (2002) Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease impact of thiopurine s-methyltransferase polymorphism. Pharmacogenetics, 12, 429-438. 

One of the main messages of the 2001 American Association of Cancer Research meeting was this variability in response to drugs can lead to therapeutic failure or adverse drug reactions in individuals or subpopulations of patients [12]. It is now recognized that all patients do not react in the same way to chemotherapy, but in some cases treatment response can be predicted. Pharmacogenetics provides the opportunity to tailor drug treatments and decrease uncertainties of therapy. 

Linking pharmacogenetics and adverse drug reactions has proved fruitful in some... 

Lee CR, Goldstein JA, Pieper JA (2002) Cytochrome P4502C9 polymorphisms a comprehensive review of the in vitro and human data. Pharmacogenetics 12 251-263 Meyer UA (2000) Pharmacogenetics and adverse drug reactions. The Lancet 356 1667-1671... 

Five years have passed since the first edition of Principles of Clinical Pharmacology was published. The second edition remains focused on the principles underlying the clinical use and contemporary development of pharmaceuticals. However, recent advances in the areas of pharmacogenetics, membrane transport, and biotechnology and in our understanding of the pathways of drug metabolism, mechanisms of enzyme induction, and adverse drug reactions have warranted the preparation of this new edition. 

Correia CT, Almeida JP, Santos PE et al (2010) Pharmacogenetics of risperidone therapy in autism association analysis of eight candidate genes with drug efficacy and adverse drug reactions. Pharmacogenomics J 10 418 30... 

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