Adverse, drug reactions diseases, influence

Age, disease states, genetics, gender, nutrition, multidrug therapy use, and herbal therapies use are patient-related factors that influence the likelihood of adverse drug reactions. 

Table 4 Influence of diseases on adverse drug reactions...

Orally active agents used in the treatment of ED are more affected by aging and disease processes than are those injected intracavernosally. In addition, alterations in hepatic metabolism and/or renal clearance in the elderly man (see Chapter 6) influence the frequency of appearance of adverse reactions between several coadministered drugs in the treatment of ED. For example, the concomitant use of sildenafil and nitroglycerin is contraindicated by cardiovascular complications. Also, the use of testosterone in the presence of androgen-dependent tumors may promote tumor growth. 

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