Advantages of Standard Methods

There are distinct advantages to the use of a standard method or guideline in the evaluation of the toxicity of chemicals or mixtures  

Provides criteria as to the suitability of the test data for decision making. 

Logistics are simplified, with little or no developmental work. 

Data compiled can be combined with that of other laboratories for use when large data sets are required. Examples are quantitative structure activity research and risk assessment. 

The method establishes a defined baseline from which modifications can be made to answer specific research questions. 

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A second advantage of standard methods is that they are optimized and validated. As tire name implies, a validated method has been thoroughly tested and characterized. The performance limitations of the method are understood and quantifiable criteria for its satisfactory performance exist. As with mass spectrometers, tests can determine whether the method is working to specifications. If it is, then the data are comparable and reliable. Finally, because data generated by standard methods are comparable, it is possible to measure performance at the analyst and laboratory levels. The topics of analyst certification and laboratory accreditation will be addressed shortly. 

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