Advantages and disadvantages of methods utilising solvents

Advantages and disadvantages of methods utilising solvents Solvent-based methods have been claimed to offer the following advantages  

As indicated earlier, methods that employ solvents at atmospheric pressure appear to offer few benefits for scale-up beyond the multi-hundreds of grams and some even may be disadvantageous in that regard. With pressurised systems, however, the story is different. Such conditions can be obtained with the microwave reactors but not readily with typical glassware. Higher temperatures have led to reaction times up to three orders of magnitude shorter than those for the same preparations carried out conventionally. 

---