Adult central nervous system

Neurotrophic factors promote both cell survival and axon growth after adult central nervous system injury in-vivo 524... 

Compensatory plasticity and functional recovery can be enhanced in the injured adult central nervous system through blockade of Nogo-A 525... 

Taupin, P. (2006a). Neurogenesis in the adult central nervous system.CR Biol, 329, 465-75. 

Morshead, C.M., Garcia, A.D., Sofroniew, M.V., van Der Kooy, D. (2003). The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci, 18, 76-84. 

Taupin, P. (2006). Neural Progenitor and Stem Cells in the Adult Central Nervous System. Annals Academy of Medicine Singapore, 35, 814-7. 

Connexins are tetra-pass membrane proteins that oligomerize into hexameric hemichannels called connnexons. These gap junction proteins are encoded by a multigene family. The presence of gap junctions and the expression of connexins has been described in many areas of the developing and adult central nervous system. Up to now, only connexin (Cx) 36 and Cx45 have been found to be expressed in neurons, besides Cx43 which is expressed in the olfactory epithelium. 

Fagan AM, Gage FH (1994) Mechanisms of sprouting in the adult central nervous system cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience 58 105-125. 

CalzaL, EemandezM,Giuhani A, D Intino S, Pirondi S, SivihaS, Paradisi M, Desordi N, Giardino L (2005) Thyroid hormone and remyelination in adult central nervous system A lesson from an inflammatory-demy-ehnating disease. Brain Res Brain Res Rev 48 339-346. 

Wolswijk, G. and Noble, M., In vitm studies of the development, maintenance and regeneration of the oligodendrocyte-type-2 astrocyte lineage in the adult central nervous system, in Neumglia, Ketterman, H. and Ransom, B. R., Eds., Oxford University Press, New York, 1995, 149-161. 

Kruger, S., Sievers, J., Hanson, C., Sadler, M., and Berry, M., Three morphologically distinct types of interface develop between adult host and fetal brain transplants implications for scar formation in the adult central nervous system, J. Comp. Neuml., 249, 103, 1986. 

Haub, O., Drucker, B., and Goldfarb, M., Expression of the murine fibroblast growth factor-5 gene in the adult central nervous system, Proc. Natl. Acad. Sci. USA., 87, 8022, 1990. 

GLT protein has so far been detected exclusively in astroglial cells in the normal adult central nervous system (excluding retina see Section 4.1.3 below). Some investigators (e.g. 

Scalabrino, G. (2009). The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system Lessons learned from its deficiency. Prog. Neurobiol. 88, 203-220. 

Peripheral neuropalbies anemia in adults central nervous system defects in children... 

Neuronal Chemokine Receptor Expression in the Adult Central Nervous System... 

Jiao, J. and D. F. Chen. 2008. Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals. Stem Cells 26 1221-1230. 

When added to the medium of neurons or astrocytes in culture, radioactive anandamide is rapidly taken up by the cells this process occurs with the rapid time-course, high affinity, temperature-dependence, saturability and selectivity typical of a carrier-mediated uptake (Fig. 6.11). Further experiments will have to address the precise mechanism and kinetic properties of this uptake system in neurons and astrocytes, in order to determine which of these cell types takes up anandamide more effectively. Also, it will be essential to establish whether anandamide uptake is present in the adult central nervous system and whether it is localized to synaptic fields where anandamide release is expected to take place (e.g., where cannabinoid receptors are localized). 

---