3 Adrenergic receptor antagonist pharmacological effects

Murmann, W., Rumore, G. and Gamba, A. (1967) Pharmacological properties of l-(4 -nitrophenyl)-2-isopropylamino-ethanol (INPEA), a new beta-adrenergic receptor antagonist. V. Effects of the optical isomers D(minus) and L(plus) INPEA on heart rate, oxygen consumption and body temperature and on the cardiac and metabolic effects of adrenaline and noradrenaline in urethane-anesthetized rats. Boll. Chim. Farm., 106, 251-268. 

Rarely, bladder ontlet obstmction may be caused by a functional obstmction at the level of the bladder neck. Hypertrophy of the smooth mnscle fibers at the level of the bladder neck in men and women may result in obstruction to the flow of nrine. In those patients who fail pharmacologic therapy with a-adrenergic receptor antagonists, endoscopic incision using the cy stoscope is highly effective in treating this very nncommon condition. 

PHARMACOLOGICAL EFFECTS The fi blockers vary in their lipid solubility, selectivity for the /Ij adrenergic receptor subtype, presence of partial agonist or intrinsic sympathomimetic activity, and membrane-stabilizing properties. While all of the P receptor antagonists are effective... 

In pharmacodynamic interactions, the pharmacological effect of a drug is changed by the action of a second drug at a common receptor or bioactive site. For example, low-potency antipsychotics and tertiary amine TCAs have anticholinergic, antihistaminic, a-adrenergic antagonist, and quinidine-Kke effects. Therefore, concurrent administration of chlorpromazine and imipramine results in additive sedation, constipation, postural hypotension, and depression of cardiac conduction. 

As of yet, the pharmacological actions of Serzone and Desyrel are not completely understood. Like SSRIs they inhibit serotonin uptake. There is also evidence that they antagonize 5-HT2 serotonin receptors. Because of these two functions, Serzone and Desyrel are often referred to as SARIs (serotonin antagonists/reuptake inhibitors). Serzone also inhibits norepinephrine reuptake while Desyrel slightly stimulates alpha-adrenergic receptors. These small differences in pharmacological action can cause widely varying side effects, which will be discussed later on. 

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