Adrenergic receptor agonists and antagonists

Gobert, A, Lejeune, F., Rivet, J. M. et al. (1995). Modulation of the activity of central serotoninergic neurons by novel serotoniniA receptor agonists and antagonists a comparison to adrenergic and dopaminergic neurons in rats. J. Pharmacol. Exp. Ther. 273, 1032-46. 

A. Miklavc, D. Kocjan, J. Mavri, J. Roller and D. Hadzi, On the fundamental difference in thermodynamics of agonist and antagonist interactions with P-adrenergic receptors and the mechanism of entropy-driven binding. Biochem. Pharmacol., 40 (1990) 663-669. 

The adrenergic receptors have been purified and their genes cloned. They have seven membrane-spanning units, which are involved in binding the selective agonists and antagonists. 

Fig. 3.4. Structure of important agonists and antagonists of adrenalin and their affinity for the P-adrenergic receptor (source Lefkowity et al., 1976).

Weiland GA, Minneman KP, Molinoff PB (1979) Fundamental difference between the molecular interactions of agonists and antagonists with the beta-adrenergic receptor. Nature 281(5727) 114-117... 

Neubig, R. R., Gantzos, R. D., and Thomsen, W. J. (1988). Mechanism of agonist and antagonist binding to alpha-2 adrenergic-receptors—evidence for a precoupled receptor guanine-nucleotide protein complex. Biochemistry 27, 2374-2384. 

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