ADME test system

High-throughput screening is the description of an airay of technologies to speed up the testing of compounds from various sources (natural or synthetic) for their parameters such as effects with specified test systems and ADME. 

This edition incorporates a new trend in drug discovery namely the consideration of pharmacokinetics and ADME properties of drugs (absorption, distribution, metabolism, excretion) early in the process. As prospective new drugs are tested in more complex systems (with... 

This raises the key test of target validation. Does a compound that has the appropriate potency, selectivity, and ADME properties, that is active in "predictive" animal models, and is free of other systems toxicology work in the targeted human disease state This is the ultimate test of a target-based drug discovery program. With the considerable compound attrition rates in moving from animals to diseased humans, this has not proven to be a predictable transition. A case in point is that of the NKl receptor activated by the peptide, substance P. 

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