Adjustment for Differences in Body Size Caloric Requirement Approach

3 Adjustment for Differences in Body Size Caloric Requirement Approach 

The caloric requirement, or metabolic rate approach, has also been proposed as an alternative to correction for differences in body size based on body weight. 

A number of parameters such as, e.g., renal clearance, basal oxygen consumption (metabolic rate), area under the curve (AUC), maximum metabolic velocity, or cardiac output correlate to the body weight to the power of 0.75 Further support for the power of 0.75 comes from a more 

It is important to note that extrapolation using allometric scaling based on metabolic rate assumes that the parent compound is the toxic agent and that the detoxification is related to the metabolic rate and thus controls the tissue level. This is relevant for oral exposure only (ECETOC 2003). 

Feron et al. (1990) have concluded that, in general, adjustment for differences in body size between experimental animals and humans should be based on caloric requirement (energy metabolism) as this was considered to be both scientifically sound and of practical significance. 

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