Adipyl hydrazide

B. Putrescine dihydrochloride. A 2-1. wide-mouthed Erlen-meyer flask containing 200 ml. of concentrated hydrochloric acid and 400 g. of cracked ice is clamped in an ice-salt bath and provided with an efficient stirrer (inefficient stirring may lower the yield). The stirring is started, and 80 g. (0.46 mole) of adipyl hydrazide is added all at once, followed by 500 ml. of ether (Note 5). While the temperature is maintained below 10° (Note 6), a solution of 80 g. (1.15 moles) of sodium nitrite in 150 ml. of water is added over about 30 minutes through a dropping funnel whose stem reaches below the bottom of the ether layer, but not into the path of the stirrer. The operations in the next paragraph should be conducted without delay after the completion of the addition of the nitrite. 

The melting point of adipyl hydrazide reported in the literature is 171° however, values as high as 179° have been observed. The checkers observed values of 174-177° and 179-181° for products of two runs, when the crystals were placed on a hot stage alter the temperature had reached 160°. 

Putrescine dihydrochloride has been prepared by the Hofmann degradation of adipamide 3.. s by the Curtius degradation of adipyl hydrazide through the urethane by the Curtius degradation of adipyl azide obtained from adipyl chloride and sodium azide by the Schmidt degradation of adipic acid with hydrogen azide by the reduction of succinonitrile, succinaldoxime, or 7-phthalimidobutyronitrile with sodium and from N-ben-zoyl-7-iodobutylamine ... 

Adipic Acid Atlde or Adipylazide (Adipinyl-azide), N3. CO(CH,)4CO. OH-not found in Beil or CA through 1956 Adipic Acid Diazide or Adipyldiazide (Adi piny Idi azide), Ns, CO(CH()4CO. N mw 196.17,N 42.84% col oil solidifying at -1° to wh crysts bp-expl viol on heating directly or under w easily sol in ale or eth. Was first prepd in 1915 from adipyl hydrazide,... 

Addition, of potassium cyanide to diethyl benzalmalonate, 30, 84 of sodium bisulfite, to cyclo-heptanone, 34, 25 to phenanthrenequmone, 34, 76 Adipyl azide, 36, 70 Adipyl hydrazide, 36, 69 Alanine, 33, 1 Aldehjde collidine, 30, 42 Aldehydes, stabilization against autoxidation, 37, 40 Aldehyde synthesis, 31, 92... 

N 428455 col oil solidifying at -1° to wh crysts bp expl viol on heating directly or under w easily sol in ale or eth. Was first prepd in I915 from adipyl hydrazide,... 

Di- and Poly-carboxylic Acids. Preparation of Diamines. The presence of more than one carboxyl group does not interfere with the conversion of the acids to the amines. Adipyl hydrazide is formed from the... 

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