Adiposin

Recently, pseudo-oligosaccharidic enzyme-inhibitors acarbose (3) [6], trestatins (4) [7], adiposins (5) [8], S-AI [9, 10], and oligostatins [11, 12] have been found in fermentation beers (Scheme 3, 4, 5). 

Ogawa, S., Shibata, Y. (1988). Total synthesis of acarbose and adiposin-2, J. Chem. Soc., Chem. Commun., p. 605. 

A further structural type of G. i. are the pseudooligosaccharides. These include as a-glucosidase inhibitors the amylostatins (e.g., acarbose), adiposins, oligo-statins, and trestatins. 

The same group has also reported an analogous synthesis of the pseudo-trisaccharide adiposin-1 (43). ... 

O-AcetyI-m -inositol, 1-32 AcetyIparomomydn I, P-13 Acorn sugaj Q-6 Adiposin 1, A-55 Adiposin 2, A-56... 

The oligosaccharides acarbose and adiposin-2 have been synthesized by coupling protected valienamine to a trisaccharide 3",4"-epoxide derived from 1",6"-anhydro-maltotriose the anticipated... 

A total synthesis reported for the pseudo-tetrasaccharide oc-gluc-osldase inhibitor acarbose and its hydroxylated analogue adiposin involved converting 1,6-anhydromaltotriose into 3",4"-anhydro analogues which were then condensed with 4,7 5,6-di-0-isopropylidene-valienamine.A synthesis of dihydroacarbose is referred to in Chapter 4. 

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