Adipogenesis and Obesity

It is now believed that physical activity has a more positive role in reducing fat in an obese person. Drugs used for obesity, fenfluramine and dextrofenfluramine, were licensed and later withdrawn from the market because of the incidence of pulmonary hypotension and heart valve defects in patients. The drugs, that are under development are leptin, cholecystokinin promoters, and troglitazone. At present, there are no safe drugs that are effective in the treatment of obesity. All one can usefully say to the obese patient is, stick to the diet, keep jogging, and seek medical advice. 

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Ziouzenkova, O., G. Orasanu, M. Sharlach et al. 2007a. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 13(6) 695-702. 

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