Adenosine 3-amino-3-deoxy

With tetrazole-A-thiocarboxylate the amino group of an OH-protected deoxy-adenosine is converted into a thiocarbamate 189 ... 

The interesting observation has been made that 3 -amino-3 -deoxy-adenosine as a suspension in phosphoryl chloride-triethyl phosphate at 4° is converted into the 5 -chloro-5 -deoxy derivative in 80% yield, but that predissolution of the nucleoside in triethyl phosphate, followed by treatment with phosphoryl chloride at 0°, yields the 5 -phosphate in 62% yield.382... 

A photoreactive nucleotide, 8-bromo-2 -deoxy-adenosine, was incorporated post-synthetically into a DNA sequence (35, Fig. 13) within the previously determined DNA contact site for the transcription factor. Upon irradiation the resulting nitrene cross-linked primarily to the 50-kDa subunit and covalently modified Lys-244. On the other hand, that amino acid residue appeared not... 

Little effort has been devoted to ascertain how the coenzyme is re-formed (the termination step). In the radical initiation step (ii, Figure 3), deoxyadenosine is formed. To re-form the Co-C bond to the 5 position of the nucleoside, a methyl group in the 5 -deoxy adenosine must be activated. Such activation requires either H atom abstraction, perhaps by the amino acid side chain radical or by a rearranged radical intermediate derived from the substrate (iv, Figure 3). This step is still not well understood. In the first edition of this volume [75], I expressed the hope that the steps that regenerate the coenzyme would become obvious once the rearrangement process was understood. Recent studies [67] to be described... 

A phosphorylase from Escherichia coli has been purified it is specific for 2-deoxy-D-ribosyl phosphate, but can use uracil, 2-thiouracil, 5-amino-uracil, 5-bromouracil, and 2-thiothymine as a pyrimidine. Deaminases of adenosine, 2-deoxyadenosine, cytidine, and 2-deoxycytidine have been detected in Escherichia coli. 

Synonyms (S)-3 -((2-Amino-3-(4-methoxyphe-nyl)-l-oxopropyl)amino)-3 -deoxy-N,N-dimethyl-adenosine Achromycin Stillomycin... 

Page 229, formula, carbon atom bearing NHj group in phenylalanine residue. For CHj, read CH. In the name, insert 3-deoxy- as the first entry inside the square brackets. However, a preferable name is 3-( -amino-p-methoxyhydrocinnamamido)-3-deoxy-V, iV-dimethyl-adenosine. 

Reversibility in the reaction of (5)-2-aminopropanol allowed the identification of 5 -deoxyadenosine as a transiently and reversibly formed intermediate. Reaction of this substrate led to both cob(II)alamin and 5-deoxyadenosine in the steady state. Experiments with [5 - H2]adenosylcobalamin and (5)-2-amino[l- H2]propanol produced 5 -deoxy-[ H3]adenosine in the steady state, proving direct hydrogen transfer from the substrate to C5 of coenzyme Bi2. ... 

The yeast nucleoside containing a thio sugar has been shown to be 6-amino-9-(5-d-methyl-5-thio-D-ribofuranosyl)-9i/-purine []5-deoxy-5-(methyIthio)adenosine] (130). 

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