Additives alprostadil

In addition to its other properties, interest in the potential use of the vasodilative properties of prostaglandin El, alprostadil ( ), has led to several conceptually different syntheses.For this purpose, the classic Corey process has to be modified by reversing the order of addition of the side chains to allow for convenient removal of the unwanted double bond in the upper side chain. For example, Corey lactone is protected with dihydropyran (acid catalysis), reduced to the lactol with diisobutyaluminum hydride, and then subjected to the usual Wittig reaction to give intermediate This is... [Pg.2]

ANTI HYPERTENSIVES AND HEART FAILURE DRUGS PROSTAGLANDINS -ALPROSTADIL t hypotensive effect Additive hypotensive effect Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... [Pg.52]

MOXISYLYTE PROSTAGLANDINS-ALPROSTADIL Risk of priapism if intracavernous alprostadil is given with moxisylyte Additive effect Avoid co-administration... [Pg.135]

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