Addition of Organozincs to Carbonyl Compounds

In general, rather forcing conditions are required for the alkylation of aldehydes by dialkylzinc reagents. However, the addition of small amounts of aminoalcohol 

Catalysis in Asymmetric Synthesis 2e 2009 Vittorio Caprio and Jonathan M.J. Williams 

A few of these ligands are illustrated, including the camphor-derived ligand (6.03) (which was the first one to give high enantioselectivies), the norephedrine-derived aminoalcohol (6.04), the praline-derived ligand (6.05), aminoalcohols with axial chirality such as binaphthyl (6.06) and ferrocene-based aminoalcohols such as (6.07).  

Many ligands capable of providing high selectivity 

Whilst much of the published work in this field focusses on the addition of diethylzinc to simple arylaldehydes, many other possibilities have been reported, as demonstrated by the examples given in the schemes. Aldehydes (6.08-6.11) are all converted in goodyields into the enantiomerically enriched alcohols (6.12-6.15) by catalysed addition of simple dialkylzinc reagents. 

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