Adaptive immune system defects

Evidence for the importance of serum MBP in the immune system has come from the identification of a deficiency syndrome in humans [47,48]. This common genetic defect is characterized by an increased susceptibility to infections particularly during the first few years of Ufe, before the adaptive immune system is fully established. Low titers of MBP are isolated from patients with this disorder [45]. Furthermore, the proteins consist predominantly of low molecular weight covalent structures that are inefficient at fixing complement, suggesting that both assembly and complement fixation are defective [40]. 

NF-kB regulates both innate and adaptive immune responses ( immune defense) [2]. Understanding the function of NF-kB in the development, maintenance, and activation of cells from the immune system (including hematopoietic cells, macrophages, dendritic cells, B and T lymphocytes) has greatly benefited from the analysis of knockout mice in which individual NF-kB family members were defective. 

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