Adaptation of Chemoreceptor Neurons During Chronic Hypoxia

Adaptation of Chemoreceptor Neurons During Chronic Hypoxia 

Important signaling elements in the chemoreflex pathway are chemoafferent nexuons with cell bodies in the petrosal ganglia. In the past these elements have been largely ignored as possible adaptive components in VAH owing to the prevailing concept 

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Evidence that hypoxia-induced adaptation of ventilatory control directly involves peripheral sensory neurons has been provided by Prabhakar et al. (86,87), who showed that 12-24 hr of hypobarie hypoxia elevates the mRNA transeript for the neuronal form of NOS (nNOS) more than 10-fold in nodose gangha cells 

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IV. Adaptation of Chemoreceptor Neurons During Chronic Hypoxia... 

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