Adams/Smith total synthesis

In 2012, Adams and Smith reported the first total synthesis of (+)-scholar-isine A (12), efforts which also constituted the first enantioselective synthesis... 

Smith AB III, Adams CM, Kozmin SA, Paone DV. Total synthesis of (—)-cylindrocyclophanes A and F exploiting the reversible nature of the olefin cross metathesis reaction. J. Am. Chem. Soc. 2001 123 5925-5937. 

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