Acylcholine acylhydrolase

Acetylcholinesterase (EC 3.1.1.7) (AChE) Acetylcholine acetylhydrolase True ChE ChE I ChE Acet-ylthiocholinesterase Acetylcholine hydrolase Acetyl (3-methylcholinesterase Erythrocyte ChE Butyrylcholinesterase (EC 3.1.1.8) (BChE or BuChE) ChE Pseudocholinesterase Plasma ChE Acylcholine acylhydrolase Non-specific ChE ChEII Benzoylcholinesterase Propionylcholinesterase... 

Cholinesterase Acylcholine acylhydrolase, butyrylcholinesterase, pseudocholinesterase Choline esters and other esters... 

This enzyme [EC 3.1.1.8] (also known as cholinesterase, pseudocholinesterase, acylcholine acylhydrolase, nonspecific cholinesterase, and benzoylcholinesterase) catalyzes the hydrolysis of an acylcholine to generate choline and a carboxylic acid anion. A variety of choline esters and a few other compounds can serve as substrates. 

Acetyl-chohnesterases (AChE, EC 3.1.1.7, also called true cholinesterase) and acylcholine acylhydrolases (or pseudocholinesterases including butyryl-cholinesterase, BuChE, EC 3.1.1.8) are commercially available enz5mies from different biological sources that catalyse the hydrolysis of acetyl- or butyryl-choline into choline and acetate or butyrate, respectively, according to the following reaction ... 

Cholinesterases (ChEs) are a ubiquitous group of enzymes that hydrolyze esters of choline. A well-known example is acetylcholinesterase (AChE, acetyl choline hydrolase, EC 3.1.1.7), the enzyme responsible for hydrolyzing the important neurotransmitter acetylcholine (ACh). Another ChE is butyrylcholi-nesterase (BuChE, acylcholine acylhydrolase, EC 3.1.1.8), also known as nonspecific cholinesterase. The preferred substrate for AChEs is ACh BuChEs prefer to hydrolyze esters like butyrylcholine and propionylcholine. Both AChE and BuChE are inhibited by some organophosphate (OP) and carbamate (CB) esters and also by other chemicals. 

Acylcholine acylhydrolase Pseudochoiinesterase, benzoyl.. cholineesterase II (scrum cholinesterase). - ChL (SChE)... 

The other cholinesterase is acylcholine acylhydrolase (EC 3.1.1.8, acylcholine acylhydrolase, CHE) it is also called pseudocholinesterase, serum cholinesterase, butyryl-choHnesterase, or choline esterase II. Although it is found in the liver, pancreas, heart, white matter of the brain, and serum, its biological role is unknown. The assay of this enzyme is clinically useful. 

Pseudocholinesterase. Acylcholine acylhydrolase. Butyrylcholine esterase. Non-specific cholinesterase. 

There are two main enzymes of interest. Acetylcholinesterase (AChE EC 3.1.1.7) has an affinity for the substrate acetylcholine and it is found in the erythrocytes and nervous tissue. The enzyme is sometimes referred to as true cholinesterase, and it exists in differing polymorphic forms (Skau 1985). Butyrylcholinesterase (BuChE, acylcholine acylhydrolase, EC 3.1.1.8)—also known as pseudocholinesterase or nonspecific cholinesterase— has affinities for the substrates butyrylcholine and/or pro-pionylcholine, which are dependent on the animal species (Myers 1953 Ecobichon and Comeau 1973 Scarsella et al. 1979 Unakami et al. 1987 Evans 1990 Matthew and Chapin 1990 Woodard et al. 1994). 

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