Acyl group transfer reactions

Acid anhydrides can also react with an alcohol. This reaction produces an ester and a carboxylic acid. This is an example of an acyl group transfer reaction, as shown in the following general reaction ... 

Acetyl CoA carries the acetyl group from glycolysis or fj-oxidation of a fatty acid to an intermediate of the citric acid cycle. This reaction is an example of an acyl group transfer reaction. In this case, the acyl group donor is a thioester— acetyl CoA. The acyl group being transferred is the acetyl group, which is transferred to the carbonyl carbon of oxaloacetate. This reaction is shown here ... 

The reaction between butanoyl chloride and methanamine to produce N-methylbutanamide is an example of an acyl group transfer reaction. 

Acyl group transfer reactions are described in Section 15.4. 

In an acyl group transfer reaction, the acyl group of an acid chloride is transferred from the Cl of the acid chloride to the N of an amine or ammonia. The product is an amide. 

Williams, A. (1989) Goncerted mechanisms of acyl group transfer reactions. Acc. 

LIpolc acid, 6-thioctic acid, (+)-S[3-(l,2-dithiola-nyl)j ptntanoic acid a coenzyme of hydrogen transfer and acyl group transfer reactions. L. a. is a component of the pyruvate dehydrogenase and the 2-oxo-glutarate dehydrogenase complexes (see Multienzyme complexes), which catalyse the oxidative decarboxylation of the corresponding 2-oxoacids (see also Tricarboxylic acid cycle). The natural form of L.a. is... 

Ester interchange by acyl-group transfer [reaction (10)] occurs readily in dilute aqueous solutions even in the absence of enzyme (4, 45, 40). 

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