Acute respiratory distress syndrome corticosteroids

Brun-Buisson C, Brochard L. Corticosteroid therapy in acute respiratory distress syndrome Better late than never JAMA 1998 280 182-183. 

Biffl WL, Moore FA, Moore EE, et al. Are corticosteroids salvage therapy for refractory acute respiratory distress syndrome Am J Surg 1995 170 591-596. 

Treatment of acute respiratory distress syndrome (ARDS) or acute lung injury may be defined as a condition involving impaired oxygenation. The nonpharmacologic therapies include mechanical ventilation. The pharmacologic therapies include the use of exogenous surfactant, corticosteroids, acetylcysteine (antioxidant), ketoconazole, nitric oxide, eicosanoids and their inhibitors, sodium nitroprus-side (vasodilator), pentoxifylline, antiendotoxin, and anticytokine therapy and antibiotics. 

Steinberg KP, Hudson LD, Goodman RB, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006 354(16) 1671-1684. 

A rare form of rheumatoid involvement of the lung is an acute pneumonitis characterized by diffuse alveolar damage (24). Some cases of this disorder have occurred within a week of stopping corticosteroids with a presentation akin to the acute respiratory distress syndrome (ARDS). 

London L, Majeski El, Altman-Hamamdzic S, et al. Respiratory reovirus 1/L induction of diffuse alveolar damage pulmonary fibrosis is not modulated by corticosteroids in acute respiratory distress syndrome in mice. Chn Immunol 2002 103 284-295. 

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