Acute renal failure interstitial nephritis and

The concomitant administration of ibuprofen antagonizes the irreversible platelet inhibition induced by aspirin. Thus, treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin. Rare hematologic effects include agranulocytosis and aplastic anemia. Effects on the kidney (as with all NSAIDs) include acute renal failure, interstitial nephritis, and nephrotic syndrome, but these occur very rarely. Finally, hepatitis has been reported. 

Cahan DH, UccI AA. Acute renal failure, interstitial nephritis, and nephrotic syndrome associated with captopril. Kidney Int 1984 25 160. 

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