Acute renal failure dextran

Dextrans may also promote a number of negative efleets. Dextrans 40 and 70 have been associated with acute renal failure, although the meehanism by whieh this is induced is unclear. Infusion of dextrans ean also prompt severe anaphylaetie shoek. Many patients exhibit anti-dextran antibodies, ineluding some who have not been previously administered dextran (antibodies may be generated in response to dextran-like dietary or baeterial polysaccharides to which the patient has previously been exposed). 

Ferraboli R, MaUieiro PS, Abdulkader RC, Yu L, Sabbaga E, Burdmann EA. Anuric acute renal failure caused by dextran 40 administration. Ren Fail 1997 19(2) 303-6. 

Schwarz J, Ihle B, Dowling J. Acute renal failure induced by low molecular weight dextran. Aust NZ J Med 1984 14(5) 688-9. 

Stein HD. Dextran-40, acute renal failure, and elevated plasma oncotic pressure. N Engl J Med 1988 318(4) 253. 

Brooks D, Okeefe P, Buncke HJ. Dextran-induced acute renal failure after microvascular muscle transplantation. Piast Reconstr Surg 2001 108(7) 2057-60. 

Vos SC, Hage JJ, Woerdeman LA, Noordanus RP. Acute renal failure during dextran-40 antithrombotic prophylaxis report of two microsurgical cases. Ann Piast Surg 2002 48(2) 193-6. 

Kato A, Yonemura K, Matsushima H, Ikegaya N, Hishida A. Complication of oliguric acute renal failure in patients treated with low-molecular weight dextran. Ren Fail 2001 23(5) 679-84. 

Dormer HR, Sondheimer JH, Cadnapaphornchai P. Mannitol-induced acute renal failure. Medicine 1990 69(3) 153-159. Mansbach AB, Madden SC, Latta H. Light and electron microscopic changes in proximal tubules of rats after administration of glucose, mannitol, suctose or dextran. Lab Invest 1962 11 421-432. 

The role of Dextran 40 (= low molecular weight dextran) in inducing acute renal failure has been reviewed (27), and its mechanism discussed. The recently reported acute glomerulonephritis appears to be mediated through a hypersensitivity phenomenon. Osmotic nephropathy is a well-known complication of dextran infusion. In dehydrated states Dextran 40 is concentrated in the proximal tubules, producing a viscid fluid which can cause tubular obstruction. 

Biesenbach G, Kaiser W, Zazgornik J. Incidence of acute oiigoanuric renal failure in dextran 40 treated patients with acute ischemic stroke stage III or IV. Ren Fail 1997 19(l) 69-75. 

Kurnik BR, Singer F, Groh WC. Case report dextran-induced acute anuric renal failure. Am J Med Sci 1991 302(l) 28-30. 

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