Proton pump inhibitors acute interstitial nephritis

Example In follow-up of the receipt of 7 reports acute interstitial nephritis (AIN) by the Netherlands Pharmacovigilance Centre Lareb, the databank of World Health Organisation Collaborating Centre for International Drug Monitoring in Uppsala, Sweden (containing about 3.7 million spontaneous reports from more than 80 countries worldwide) was searched for cases of AIN. A total of 150 AIN cases with recorded proton-pump inhibitors (PPI) use was found. The proportionality of PPI use within the AIN cases was compared to the same in the rest of all 3.7 million reports, resulting in a ROR of 9.4 for omeprazole. 

Harmark L, van der Wiel HE, de Groot MC, van Grootheest AC. Proton pump inhibitor-induced acute interstitial nephritis. Br J Clin Pharmacol 2007 64 819-23. 

Proton pump inhibitors acute interstitial nephritis and other renal effects... 

Simpson IJ MM, Pilmore H, Manley P, Williams L,Thein H, Voss D. Proton Pump Inhibitor and acute interstitial nephritis Report and aniysisof IScases. Nephrology 2006 11 381-5. 

Geevasinga N, Coleman PL, Webster AC, Roger SD. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol 2006 4(5) 597-604. 

Acute allergic interstitial nephritis Penicillins Ciprofloxacin Nonsteroidal anti-inllammatoiy drags, cyclooxygenase-2 inhibitors Proton pump inhibitors Loop diuretics... 

Krishnamurthy M, Snyder R, Bachurina M. Long-term use of proton pump inhibitors are they really safe A case of delayed acute interstitial nephritis. J Am Geriatr Soc 2009 57 1513-A. 

Urinary tract In a case-control study the risk of acute interstitial nephritis (AIN) and acute kidney injury (AKI) was estimated for exposure to nonselective NSAIDs (nsNSAIDs), (proton pump inhibitors) PPIs and co-exposure to both (nsNSAID + PPI). There were 68 AIN cases identified from a primary care database from the United Kingdom (Clinical Practice Research Datalink) who were matched to 3347 controls. The risk of AIN for use of PPIs only was 3.2 (95%CI 0.8-12.8), of nsNSAIDs only was 1.9 (95%CI 0.7-5.5) (Cl, confidence interval). For individual nsNSAIDs diclofenac showed an odds ratio (OR) of 2.7 (95%CI 0.6-10.9) piroxicam provided an OR of 28.0 (2.2-365.1), however, the estimates are affected by the small number of cases and matched controls. Regarding AKI (n=27,982 cases n= 1,323,850 matched controls), the risk was increased by 31% for use of nsNSAIDs only (OR 1.31 95%CI 1.25-1.37) and for nsNSAIDs + PPI by 33% (OR 1.33 95%CI 1.07-1.64) [2 =]. 

Leonard CE, Freeman CP, Newcomb CW, Reese PP, HerUm M, Bilker WB, et al. Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury. Pharmacoepidemiol Drug Saf November 2012 21(ll) 1155-72. 

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See also in sourсe #XX -- [ ]

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