Acute coronary syndrome pathogenesis

Fuster V, Badimon L, Badimon JJ, et al. (1992a) The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 326 242-250... 

Platelet aggregation plays a critical role in the pathogenesis of acute coronary syndromes with increasing evidence that antiplatelet therapy reduces cardiovascular disease risk [Awtry and Loscalzo, 2000]. The effect of dietary flavonoids to reduce platelet activity may provide an important mechanistic explanation for the available epidemiological data regarding flavonoids and cardiovascular disease. 

Fuster V, Baifimon L, Badimon JJ, Ches o JH Hie pathogenesis of coronary artery disease and die acute coronary syndromes. Part 2. New Eng J of Med 326 310,1992... 

Platelet aggregation plays an important role in the pathogenesis of acute coronary syndromes (ACS). Myocardial infarction is an ACS that occurs when atherosclerotic plaques embedded in artery walls rupture, leading to thrombus formation and coronary occlusion. Patients with high-risk coronary stenosis may need percutaneous coronary interventions (PCI) with or without stent placement to revascularize the arteries. 

Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001 104 365-72. 

Atherosclerotic plaque rupture is a key event in the pathogenesis of acute coronary syndromes and during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the entire epicardial coronary artery with subsequent acute myocardial infarction, but may in milder forms result in the embolization of atherosclerotic and thrombotic debris into the coronary microcirculation. 

Impressive advancements in the treatment of acute coronary syndromes and congestive heart failure have been introduced in recent years. This has relied on a better understanding of the underlying pathogenesis... 

Leschka S, Alkadhi H et al. (2005) Accuracy of MSCT coronary angiography with 64-slice technology first experience. Eur Heart J 26 1482-1487 Libby P (2001) Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104 365 372 Lima RS, Watson DD et al. (2003) Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease. J Am Coll Cardiol 42 64-70... 

Aberrant thrombus formation and deposition on blood vessel walls imderlies the pathogenesis of acute cardiovascular disease states which remain the principal cause of morbidity and mortality in the industrialized world [1,2,3]. Plasma proteins, proteases and specific cellular receptors that participate in hemostasis have emerged as important risk considerations in thrombosis and thromboembolic disorders. The clinical manifestations of the above disease states include acute coronary artery and cerebrovascular syndromes, peripheral arterial occlusion, deep vein thrombosis and pulmonary/renal embolism [3]. The most dilabilitating acute events precipitated by these disorders are myocardial infarction and stroke. In addition, the interplay between hemostatic factors and hypertension (4) or atherosclerosis (5) dramatically enhances the manifestation of these pathologic states. 

The pathogenesis of the sudden death syndrome has been postulated to be due to withdrawal of coronary vasodilators (e.g., NG), resulting in vasoconstriction with acute hyper-... 

Coronary artery spasm may account for a variety of clinical syndromes such as variant angina, acute myocardial infarction and sudden cardiac death [94]. The mechanisms of vasospasm however are not entirely clear. Atherosclerosis and hypercholesterolemia have been implicated in the pathogenesis of vasospasm [95-97] and a local hyperactivity of the coronary artery may be involved. 

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