Activity in human cancer cell

SET7/9 modulates p53 activity in human cancer cells in vitro and in vivo [22] and also regulates NF-/vB-dependent inflammatory genes [31]. 

Watanabe, T. and Sullenger, B.A. (2000) Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. I roc. Natl. Acad. Sci. USA, 97, 8490-8494. 

Reaction of amino diols with a fatty acid afforded a series of simple ceramide analogs with pro-apoptotic activity in human cancer cell lines (160). An example is Ai-oleoylserinol, which induced apoptosis in cells expressing the pro-apoptotic protein PAR-4 and was used to purge transformed cells from embryonic stem cells before implantation into mouse brain (161). 

Ciardiello F, Caputo R, Bianco R, Dami-ano V, Pomatico G, et al. 2000. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. 6 2053-63... 

Theaflavins efficiently and specifically inhibited the proteasomal chymotrypsin-like activity of the purified mammalian 20S and 26S proteasomes in cell-free systems (figure 11.3) as well as 26S proteasomes in tumor cell extracts (table 11.1). The purified M. thermophila recombinant 20S proteasome was more sensitive to theaflavins than mammalian 20S or 26S proteasomes, possibly due to prokaryotic recombinant 20S proteasome without postmodification that forms steric hindrance that prevents theaflavins from binding to the chymotrypsin-like activity subunit of the 20S proteasome. When assaying for proteasomal chymotrypsin-like activity in human cancer cell extracts, the IC50 values of tea polyphenols were apparently increased compared... 

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