Active pharmaceutical ingredient Particle size distribution

Recrystallization of an active pharmaceutical ingredient on a spinning disc, employing a solvent/antisolvent approach to induce rapid precipitation, results in the desired small particles (1-15 microns) and narrow particle size distribution (59). 

In many processes, such as coating or layering granulation, the width (or variance) of the particle property distribution is an important measure of product quality. The variance in particle size is directly related to the variance in thickness of the coating layers that has great influence on the product characteristics, for example the release time of active ingredients in pharmaceuticals. 

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