Activator OT Urea

COMPOUND NAME, PAGE Activator OT Urea, 37 Markstat 51,263 Markstat 51,264 Markstat 51,265 Cyanox STDP, 81 Cyanox LTDP, 79 Stearic Acid, 313 Polycizer Butyl Oleate, 287 Butyl ricinoleate, 195 Flexol EP-8, 231 Flexol EP-8, 233 Flexol EP-8, 232 Epoxidized linseed oil, 229 Epoxidized linseed oil, 227 Epoxidized linseed oil, 228 Cure-Rite IBT, 35 Dioctyl maleate, 223 Isonox 232, 111 Ethaphos 368, 95 Alkanox P27, 63 Kemamide E ultra, 309 Citroflex B-6, 209 Laurex , 261 Retarder AK, 311 Santicizer 278, 155 Perkacit DPG, 305... 

COMPOUND NAME, PAGE Activator OT Urea, 41 Markstat 51, 345 Markstat 51, 346 Markstat 51, 347 Cyanox STDP, 109 Cyanox LTDP, 107 Stearic Acid, 409 Poiycizer Butyi Oieate, 371 Dimethyi sebacate, 263 Butyi ricinoieate, 315 Fiexoi EP-8, 279 Fiexoi EP-8, 281 Fiexoi EP-8, 280 Epoxidized iinseed oii, 271 Epoxidized iinseed oii, 269 Epoxidized iinseed oii, 270 Cure-Rite IBT, 39 Dioctyi maieate, 265 lsonox 232, 161 Ethaphos 368, 143 Ethaphos 368, 141 Aikanox P27, 67 Kemamide E uitra, 405... 

Limited data on the toxicokinetics of ANTU are available. However, absorption does occur following oral administration. ANTU toxicity in the rat is thought to depend on metabolic activation via the hepatic and lung microsomal enzymes to form a hydrosulfide and ot-naphthyl urea. 

Formation of urea in hepatocytes. NAGS = N-acetylglutamate synthase CPSI = carbamoylphosphate synthase I OCT = ornithine carbamoyltransferase C-OT = citrulline-omithine translocase AS = argininosuccinate synthase AL = argininosuccinate lyase A = arginase. — -> indicates the absolute requirement of N-acetylglutamate for CPSI activity. 

Booker-Milburn and Lloyd-Jones in 2009 revealed the cationic palladium-catalyzed carbonylation of aryl urea derivatives at room temperature under 1 atm of CO forming the cyclic imidates [31]. Key features of this procedure are the utilization of the Pd(OTs)2(MeCN)2 as the catalyst precursor and the powerful activating effect of the aniline -urea moiety in contrast with acetanilide (0% yield). For the A/ ,A/ -disubstituted substrates (Table 15.23), the yields were dropping with the steric bulk increasing, whereas for the AT-monosubstituted analogs, the trend was opposite. Prolonged reaction time resulted in low yields which can be rationalized by the reflection that the imidate products were sensitive to the added acid. 

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