Actinide complexes amino acids

The. applications of ion-exchange chromatography are exemplified by the selection shown in table 4.18. Among the most notable are the separation of lanthanides and actinides using a citrate, lactate or EDTA eluting agent the separation of many metals as halide complexes on anionic resins and the separation of amino-acids with citrate buffers. The use of pressurized systems for complex mixtures is likely to become more widespread in the future. 

From fig. 1 it can be seen that in addition to the labile protein-bound fraction, metal-transferrin complexes in the case of actinides, there is also a low molecular mass fraction in which metal ions are bound to, and transported with, ligands such as the anions of amino and carboxylic acids. For the hard cations of the actinide elements, these complexing agents are predominantly carboxylic acids (from the citric acid cycle) (Duffield and Taylor 1986, Popplewell et al. 1975, Duffield et al. 1984, Metivier 1973) or inorganic anions such as carbonate, e.g., for uranium(VI) (Stevens et al. 1980). 

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