Actin-binding proteins, table

Table 1. The Effect of Altered Concentration of Actin-Binding Proteins on Locomotion...

Table 4.1. Properties of some actin-binding proteins...

The regulatory proteins troponin and tropomyosin 1118 Table 19-1 Some Actin-Binding Proteins... 

Various nonmuscle forms of myosin also interact with actin without formation of the myofibrils of muscle.299 In most higher organisms nonmuscle myosins often consist of two 200-kDa subunits plus two pairs of light chains of 17 and 24 kDa each. These may form bipolar aggregates, which may bind to pairs of actin filaments to cause relative movement of two parts of a cell.303 Movement depending upon the cytoskeleton is complicated by the presence of a bewildering array of actin-binding proteins, some of which are listed in Table 19-1. 

Table 1 summarizes all of the known direct interactions and effects on actin of purified coronin proteins. From this compilation, it is apparent that F-actin binding and bundling are conserved functions of coronin. Arp2/3 complex and cofilin regulation by coronin may be equally well conserved, but this remains to be determined, as biochemical tests for these activities have been limited to a few studies so far. 

If nascent actin filaments anchored to the cytoskeleton (by binding proteins such as those listed in Table 21-6)... 

Among the many functions of cytoskeletal proteins, especially those that bind actin or tubulin, is regulation of polymerization of F-artin and MTs. A comprehensive catalogue of the specific functions of each protein is beyond the scope of this review, but consideration of some basic functions of these proteins illustrates how mechanisms of polymer assembly are used to control the cytoskeleton. Selected examples of cytoskeletal-binding proteins with affinity for specific filament types are listed in Table 1. 

The decrease in the distribution volume of TNF with an increase in dose is thought to be due to capacity-limited extravascular transport processes (Table 5.3). The increase in volume of distribution of DNase with an increase in dose is thought to be due to capacity limited protein binding to actin in plasma (possibly an actin-vitamin D-DNase ternary complex). 

Gronp 2 of the LIM domains contains the Cys-rich Proteins (CRP) and Cys-rich Intestinal Protein (CRIP) subfamilies that have tandem repeats of zinc-binding sites containing the ligands CCHC and CCCC (Table 6). The structures of the chicken, qnail, and rat 84 pj-Qteins are determined by NMR. These proteins have a role in the contractile machinery of mnscle. Three vertebrate CRPs (CRP 1-3) are associated with the actin cytoskeleton, and one has been shown to be reqnired for striated mnscle sttncture and function in mnscle differentiation and fimction. ... 

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