ACTH 4-9 analog Org

Using the foot withdrawal reflex as an indicator of return of sensory function following nerve crush. Van der Zee et al. (1991) compared the competence of various melanocortins a-MSH, N-leu , D-Phe )-a-MSH, desacetyl-a-MSH and the ACTH 4-9 analog Org 2766. They found no differences in their effectiveness in eliciting the reflex. Other putative neurotrophic factors such as... 

Not only peripheral sensorimotor neuropathies are beneficially affected by the ACTH 4-9 analog Org 2766 but autonomic neuropathies, such as the crushed parasympathetic fibers of the oculomotor nerve are responsive to treatment with this neuropeptide, especially in the initial stages of regeneration. However, if the oculomotor nerve is sectioned, systemic treatment with Org 2766 improves neither the rate nor quality of functional recovery as determined by pupil diameter (Vandertop et al., 1994). 

Isaacson, R. and Poplawsky, A. (1983) An ACTH 4-9 analog (Org 2766) speeds recovery from septal hyperemotionality in the rat. Behav. Neural Biol. 39 52-59. 

Spruijt, B.M. (1992a) The ACTH 4-9 analog Org 2766 modulates NMDA receptor activity. Soc. Neurosci. Abstr. 18 897. 

Spruijt, B.M. (1992b) Effects of the ACTH 4-9 analog, Org 2766 on brain plasticity modulation of excitatory neurotransmission. Psychoneuroendology 17 315-325. 

Structure-activity studies on ACTH peptide fragments by Bijlsma et al. (1981b) showed most neurotrophic potency to be in three ACTH-like peptides ACTH 4-10, a trisubstituted analog of ACTH 4-9, Org 2766, and a-MSH. The ACTH 4-10 analog BIM 22015 has similar neurotrophic characteristics (Atella et al., 1992 Strand et al., 1993b). The structures of these peptides are shown in Table 1. The remarkable structural specificity of melanocortins is exemplified in a study which shows that a-MSH, [A-leu, D-Phe ]-a-MSH, de-sacetyl-a-MSH and Org 2766 are equally effective when tested in the foot withdrawal reflex, whereas ACTH 7-16 is without effect and ACTH/MSH... 

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