Acrylic microspheres, controlled release

Other Formulations. Neural networks have been applied to the modeling of pellet formulations to control the release of theophylline [63] and to control the rate of degradation of omeprazole [64]. They have also been applied to the preparation of acrylic microspheres [65] and to model the release of insulin from an implant [66]. In arecent study from Brazil, the release of hydrocortisone from a biodegradable matrix has been successfully modeled [67]. 

Yuksel N, Turkoglu M, Baykara T. Modelling of the solvent evaporation method for the preparation of controlled release acrylic microspheres using neural networks. J Microencapsulation 2000 17 541-51. 

Michel P.E., Gautier S.M., Blum L. J., Luciferin incorporation in the structure of acrylic microspheres with subsequent confinement in a polymeric film a new method to develop a controlled release- based biosensor for ATP, ADP and AMP, Talanta 1998 47 167-181. 

Kawashima, Y., et al. 1991. Preparation of multiple unit hollow microspheres (microballons) with acrylic resin containing tranilast and their drug release characteristics in vitro) and floating behavior in vivo). J Control Release 16 279... 

Lehr, C.-M. Bouwstra, J.A. Tukker, J.J. Junginger, H.E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat—a comparative study with copolymers and blends based on poly(acrylic acid). J. Controlled Release 1990, 13, 51-62. 

Kawashima Y, Niwa T, Handa T, Takeuchi H, Iwamoto T, Itoh K. Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. Journal of Pharmaceutical Sciences. January 1989 78(1) 68-72. PubMed PMID 2709323. 

One specific polymer type that has been employed in the spray drying of microspheres to modify release is acrylic resin. A commercial blend of neutral methacrylic acid esters was used for the preparation of spray-dried controlled release microcapsules containing model drugs (34). Dissolution results of tablets compressed from the... 

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