Acrylic acid Butyl aldehydes

We chose 2-chlorotrityl chloride resin for the attachment of acrylic acid, because in solution-phase chemistry the best results have been obtained by using aryl acrylates or (erf-butyl acrylates [21], In addition to DABCO (1,4-diazabicyclo [2.2.2]octane) - the most common tertiary cyclic amine for this type of reaction - we also used the more reactive 3-quinuclidinol (3-hydroxy-quinuclidine, 3-HQN) for the Baylis-Hillman reaction with aldehydes. We used 26 different aldehydes and obtained good to excellent purities, as determined by analytical HPLC. 

Papageorgiou and Benezra204 treated chiral r-butyl (-)-(S)- and ( + )-(R)-2-(p-tolylsulfinyl)propionate with an aldehyde, then pyrolyzed the mixture and obtained chiral a-(hydroxyalkyl)acrylate in 75% e.e. Similarly, condensation of the anion of ( + )-(R)-3-(p-tolylsulfinyl)propionic acid 159 with aldehydes was found to give the diastereomeric [i-sulfinyl-y-lactones, (+)-(Sc4,Rc5,Ps)-160a and ( + )-( c4,Sc5,l s)-160b in an approximate ratio of 60 40205. 

BUTANAMINE, n-BUTYL (111-92-2) Forms explosive mixture with air (flash point 117 F/47°C). An organic base. Violent reaction with oxidizers, acids, cellulose nitrate. Incompatible with organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, halogenated compounds, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactam solution. Attacks copper, magnesium, tin, zinc, or their alloys, and galvanized steel,... 

BUTYL BROMIDE or n-BUTYL BROMIDE (109-65-9) Forms explosive mixture with air (flash point 65°F/18°C). Violent reaction with strong oxidizers, strong acids. Incompatible with organic anhydrides, acrylates, alcohols, aldehydes, alkylene oxides, substituted allyls, cresols, caprolactam solution, epichlorohydrin, ethylene dichloride, glycols, isocyanates, ketones, maleic anhydride, nitrates, nitromethane, phenols, vinyl acetate. May accumulate static electrical charges may cause ignition of its vapors. 

In 1982, Drewes and Emslie first reported the reaction of ethyl acrylate with acetaldehyde in the presence of DABCO and successfully employed this adduct in the synthesis of integerrinecic acid (3) (Scheme 2.2). Soon after that, Hoffmann et al. developed an interesting reaction between methyl/tcrt-butyl acrylates 4 and various aldehydes rmder the catalytic influence of DABCO to provide the corresponding a-hydroxyalkyl acrylate adducts 5 and elegantly applied one of these adducts to synthesis of racemic mikanecic acid (6) (Scheme 2.3). Since then, a series of reports" have emerged and transformed the MBH reaction into a very useful and promising tool for the construction of carbon-carbon bonds in synthetic chemistry (Scheme 2.4). 

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